Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.

  title={Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.},
  author={M. Koch and T. Bugni and M. Sondossi and C. Ireland and L. Barrows},
  journal={Planta medica},
  volume={76 15},
  • M. Koch, T. Bugni, +2 authors L. Barrows
  • Published 2010
  • Biology, Medicine
  • Planta medica
  • Exocarpic acid (13 E-octadecene-9,11-diynoic acid) from Exocarpos latifolius R.Br. (Santalaceae) was previously shown to have specific antimycobacterial activity. Microarray data suggested inhibition of fatty acid metabolism as a potential mode of action. Experiments designed to elucidate the mechanism of action showed that exocarpic acid was effective at inhibition of mycolic acid biosynthesis and did not act by dissipating the proton gradient in treated M. tuberculosis. Amide derivatives of… CONTINUE READING
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