• DOI:10.1055/s-0030-1249939
Corpus ID: 41254255

Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.

@article{Koch2010ExocarpicAI,
  title={Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.},
  author={M. Koch and T. Bugni and M. Sondossi and C. Ireland and L. Barrows},
  journal={Planta medica},
  year={2010},
  volume={76 15},
  pages={
          1678-82
        }
}

M. Koch, T. Bugni, +2 authors L. Barrows

Published 2010

Biology, Medicine

Planta medica

Exocarpic acid (13 E-octadecene-9,11-diynoic acid) from Exocarpos latifolius R.Br. (Santalaceae) was previously shown to have specific antimycobacterial activity. Microarray data suggested inhibition of fatty acid metabolism as a potential mode of action. Experiments designed to elucidate the mechanism of action showed that exocarpic acid was effective at inhibition of mycolic acid biosynthesis and did not act by dissipating the proton gradient in treated M. tuberculosis. Amide derivatives of… CONTINUE READING

View on PubMed

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed