Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.

@article{Jin2005Exo84AS,
  title={Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.},
  author={Rongsheng Jin and Jagath R Junutula and Hugo T Matern and Karen E Ervin and Richard H. Scheller and Axel T Brunger},
  journal={The EMBO journal},
  year={2005},
  volume={24 12},
  pages={2064-74}
}
The Sec6/8 complex, also known as the exocyst complex, is an octameric protein complex that has been implicated in tethering of secretory vesicles to specific regions on the plasma membrane. Two subunits of the Sec6/8 complex, Exo84 and Sec5, have recently been shown to be effector targets for active Ral GTPases. However, the mechanism by which Ral proteins regulate the Sec6/8 activities remains unclear. Here, we present the crystal structure of the Ral-binding domain of Exo84 in complex with… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
59 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap

  • NI Nicely, J Kosak, V de Serrano, C Mattos
  • Structure (Camb)
  • 2004
3 Excerpts

Similar Papers

Loading similar papers…