Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons

@article{Matteoli1992ExoendocytoticRO,
  title={Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons},
  author={Michela Matteoli and Kohji Takei and Mark S. Perin and Thomas C S{\"u}dhof and Pietro De Camilli},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={117},
  pages={849 - 861}
}
In mature neurons synaptic vesicles (SVs) undergo cycles of exo-endocytosis at synapses. It is currently unknown whether SV exocytosis and recycling occurs also in developing axons prior to synapse formation. To address this question, we have developed an immunocytochemical assay to reveal SV exo-endocytosis in hippocampal neurons developing in culture. In this assay antibodies directed against the lumenal domain of synaptotagmin I (Syt I), an intrinsic membrane protein of SVs, are used to… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

Mesenchymal stem cells enhance GABAergic transmission in co-cultured hippocampal neurons.

Molecular and cellular neurosciences • 2012
View 3 Excerpts
Highly Influenced

Protein sorting in the synaptic vesicle life cycle

Progress in Neurobiology • 2006
View 4 Excerpts
Highly Influenced

Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 4 Excerpts
Highly Influenced

Synaptic targeting of N-type calcium channels in hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 3 Excerpts
Highly Influenced

The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Structural and functional conservation of synaptophysin (p65) in Drosophila and humans

M. S. Perin, P. A. Johnston, +3 authors T. C. SOdhOf.
J. Biol Chem. 266:615-622. • 1991
View 5 Excerpts
Highly Influenced

Turnover of transmitter

B. Ceccarelli, W. P. Hurlbnt, A. Mauro
1973
View 4 Excerpts
Highly Influenced

A small G protein dissociates from vesicles during exocytosis

G. Fischer v. Mollard, T. C. Siidhof, R. Jahn.
Nature (Lend.). 349:79-82. • 1991
View 1 Excerpt

Binding of synaptotagmin to the r in receptor impficates both in synaptic vesicle exocytosis

A. O. Fetrenko, M. S. Perin, +3 authors T. C. SudhOf.
Nature (Lend.). 353: 65-68. • 1991

Cosecretion of multiple signal molecules from endocrine

P. De Camilli
1991
View 1 Excerpt

Similar Papers

Loading similar papers…