Exit from mitosis in budding yeast: biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20.

@article{Yeong2000ExitFM,
  title={Exit from mitosis in budding yeast: biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20.},
  author={Foong May Yeong and Hong Hwa Lim and C G Padmashree and Uttam Surana},
  journal={Molecular cell},
  year={2000},
  volume={5 3},
  pages={501-11}
}
Cdc20, an activator of the anaphase-promoting complex (APC), is also required for the exit from mitosis in Saccharomyces cerevisiae. Here we show that during mitosis, both the inactivation of Cdc28-Clb2 kinase and the degradation of mitotic cyclin Clb2 occur in two steps. The first phase of Clb2 proteolysis, which commences at the metaphase-to-anaphase… CONTINUE READING