Exit from Competence for Genetic Transformation in Streptococcus pneumoniae Is Regulated at Multiple Levels

@inproceedings{Weng2013ExitFC,
  title={Exit from Competence for Genetic Transformation in Streptococcus pneumoniae Is Regulated at Multiple Levels},
  author={Liming Weng and Andrew Piotrowski and Donald A. Morrison},
  booktitle={PloS one},
  year={2013}
}
Development of natural competence in S. pneumoniae entails coordinated expression of two sets of genes. Early gene expression depends on ComE, a response regulator activated by the pheromone CSP (Competence-Stimulating-Peptide). Subsequently, an early gene product (the alternative sigma factor ComX) activates expression of late genes, establishing the… CONTINUE READING