Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.

@article{Nishimura1991ExistenceOT,
  title={Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.},
  author={Kazuo Nishimura and Masatsugu Ota and Kiyotaka Ito},
  journal={British journal of pharmacology},
  year={1991},
  volume={102 1},
  pages={215-21}
}
1. The mechanisms involved in the contraction of rat aorta induced by the activation of alpha 1-adrenoceptors were studied. Phenylephrine induced a phasic contraction in the aorta incubated in Ca2(+)-free medium containing 0.5 mM EGTA. Subsequent addition of Ca2+ induced a tonic contraction, which exhibited a stepwise development, an initial phase lasting 3 to 6 min (tonic-I) followed by a superimposing second phase (tonic-II). 2. 2-Nitro-4-carboxyphenyl-N,N-diphenylcarbamate, which has been… CONTINUE READING

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