Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency.

@article{Katamura1999ExistenceOA,
  title={Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency.},
  author={Kenji Katamura and Gore Tai and Takehiko Tachibana and Hirohiko Yamabe and Kyoko Ohmori and Mitsufumi Mayumi and Satoshi Matsuda and Shigeo Koyasu and Kentaro Furusho},
  journal={Clinical and experimental immunology},
  year={1999},
  volume={115 1},
  pages={
          124-30
        }
}
CD8 deficiency is a rare primary immunodeficiency caused by the defect of a tyrosine kinase, ZAP-70, which transduces signals from the T cell receptor. We report here a case of CD8 deficiency, having CD4+ T cells with a unique phenotype. The patient's T cells did not respond to anti-CD3 stimulation in vitro, suggesting that they were naive. However, many CD4+ T cells with activated and memory phenotypes, which expressed CD45RO+, HLA-DR+ and CD25+, were present in the peripheral blood, and these… CONTINUE READING
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