Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency

@article{Katamura1999ExistenceOA,
  title={Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency},
  author={Katamura and Tai and Tachibana and Yamabe and Ohmori and Mayumi and Matsuda and Koyasu and Furusho},
  journal={Clinical \& Experimental Immunology},
  year={1999},
  volume={115}
}
  • Katamura, Tai, Furusho
  • Published 1 January 1999
  • Biology, Medicine
  • Clinical & Experimental Immunology
CD8 deficiency is a rare primary immunodeficiency caused by the defect of a tyrosine kinase, ZAP‐70, which transduces signals from the T cell receptor. We report here a case of CD8 deficiency, having CD4+ T cells with a unique phenotype. The patient's T cells did not respond to anti‐CD3 stimulation in vitro, suggesting that they were naive. However, many CD4+ T cells with activated and memory phenotypes, which expressed CD45RO+, HLA‐DR+ and CD25+, were present in the peripheral blood, and these… 
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CD8 LYMPHOCYTOPENIA CAUSED BY ZAP-70 DEFICIENCY
Combined Immune Deficiencies
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