Existence of a common precursor to ACTH and endorphin in the anterior and intermediate lobes of the rat pituitary.

@article{Eipper1978ExistenceOA,
  title={Existence of a common precursor to ACTH and endorphin in the anterior and intermediate lobes of the rat pituitary.},
  author={Betty A Eipper and Richard E Mains},
  journal={Journal of supramolecular structure},
  year={1978},
  volume={8 3},
  pages={247-62}
}
Extracts of rat anterior and intermediate-posterior pituitary were fractionated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and assayed for immunoactive ACTH and endorphin. In both lobes the major forms of immunoactive ACTH have apparent molecular weights of 31,000 (31K), 20--21K, 14K, and 4.5K, and the major forms of immunoactive endorphin have apparent molecular weights of 31K (coincident with the peak of immunoactive ACTH), 13K (a betaLPH-like peptide), and 3.5K (a beta… CONTINUE READING

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The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
The isolated intermediate lobe cells synthesize and secrete relatively large amounts of a beta - endorphin - like molecule ; the isolated anterior lobe cells secrete significant amounts of both a betaLPH - like molecule and a beta - endorphin - like molecule .
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