Exhibition of anti-platelet effect of isocarbacyclin methyl ester and its free acid via an increase in cAMP in platelets.

@article{Aoki1995ExhibitionOA,
  title={Exhibition of anti-platelet effect of isocarbacyclin methyl ester and its free acid via an increase in cAMP in platelets.},
  author={Yuji Aoki and Kaori Inoue and Shuichiro Kitahara and Mamoru Kiyoki and Haruo Araki},
  journal={Arzneimittel-Forschung},
  year={1995},
  volume={45 9},
  pages={
          970-4
        }
}
Isocarbacyclin methyl ester (CAS 88931-51-5, TEI-9090) and its free acid (CAS 88911-35-7, TEI-7165) are chemically stable analogues of prostaglandin (PG) I2. The cAMP increasing activities of TEI-9090 and TEI-7165 were investigated. TEI-9090, TEI-7165, PGI2, and PGE1 caused the accumulation of cAMP in rabbit and human platelets. The effects of TEI-9090, TEI-7165, and PGE1 were longer lasting than the effect of PGI2. Each drug concentration-dependently increased the cAMP level in rabbit and… CONTINUE READING