Exhaustive methylation analysis revealed uneven profiles of methylation at IGF2/ICR1/H19 11p15 loci in Russell Silver syndrome.

@article{Azzi2015ExhaustiveMA,
  title={Exhaustive methylation analysis revealed uneven profiles of methylation at IGF2/ICR1/H19 11p15 loci in Russell Silver syndrome.},
  author={Salah Azzi and Virginie Steunou and J{\"o}rg Tost and Sylvie Rossignol and Nathalie Thibaud and Cristina Das Neves and Marilyne Le Jule and Walid Abi Habib and Annick Blaise and Yves Akoli Koudou and Florence Busato and Yves le Bouc and Ir{\`e}ne Netchine},
  journal={Journal of medical genetics},
  year={2015},
  volume={52 1},
  pages={53-60}
}
BACKGROUND The structural organisation of the human IGF2/ICR1/H19 11p15 domain is very complex, and the mechanisms underlying its regulation are poorly understood. The Imprinted Center Region 1 (ICR1) contains seven binding sites for the zinc-finger protein CTCF (CBS: CTCF Binding Sites); three additional differentially methylated regions (DMR) are located at the H19 promoter (H19DMR) and two in the IGF2 gene (DMR0 and DMR2), respectively. Loss of imprinting at the IGF2/ICR1/H19 domain results… CONTINUE READING
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