Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort.

@article{Do2005ExhaustiveGO,
  title={Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort.},
  author={H. Do and A. Vasilescu and G. Diop and T. Hirtzig and S. Heath and C. Coulonges and J. Rappaport and A. Therwath and M. Lathrop and F. Matsuda and J. Zagury},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={191 2},
  pages={
          159-63
        }
}
CEM15 (or APOBEC3G) has recently been identified as an inhibitor of human immunodeficiency virus type 1 (HIV-1) replication in vitro. To evaluate the impact of its genetic variations on the progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of CEM15. We have sequenced CEM15 in a cohort of 327 HIV-1-seropositive patients with extreme disease progression phenotypes--either slow progression or rapid progression--and in 446 healthy control… Expand
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