Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection

@article{Steger2008ExhaustiveDO,
  title={Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection},
  author={U. Steger and C. Denecke and B. Sawitzki and M. Karim and N. Jones and K. Wood},
  journal={Transplantation},
  year={2008},
  volume={85},
  pages={1339-1347}
}
Background. The precise role that CD8+ T cells play in the rejection and acceptance of different types of allograft is unclear and has been shown to vary between donor–recipient combinations. Methods. The response of adoptively transferred CD8+ T cells reactive to the donor alloantigen H2Kb was examined after transplantation of H2Kb+ liver, kidney, and heart grafts in mice. Results. After transfer of 6×106 alloreactive CD8+ T cells to T-cell depleted syngeneic mice spontaneous long-term… Expand
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