Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection

@article{Steger2008ExhaustiveDO,
  title={Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection},
  author={Ulrich Steger and Christian Denecke and Birgit Sawitzki and Mahzuz Karim and Nick D. Jones and Kathryn J. Wood},
  journal={Transplantation},
  year={2008},
  volume={85},
  pages={1339-1347}
}
Background. The precise role that CD8+ T cells play in the rejection and acceptance of different types of allograft is unclear and has been shown to vary between donor–recipient combinations. Methods. The response of adoptively transferred CD8+ T cells reactive to the donor alloantigen H2Kb was examined after transplantation of H2Kb+ liver, kidney, and heart grafts in mice. Results. After transfer of 6×106 alloreactive CD8+ T cells to T-cell depleted syngeneic mice spontaneous long-term… 
Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation
  • Szun S. Tay, B. Lu, P. Bertolino
  • Biology, Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2013
TLDR
A mouse liver transplant model is developed in which PLs, recipient cells, and a reporter population of transgenic CD8 T cells specific for the graft could be easily distinguished and quantified in allografts and recipient organs by flow cytometry and shows that alloreactive CD9 T cells are deleted more rapidly than initially reported.
Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
TLDR
The measurement of peripheral blood CD8+ effector memory T cells prior to lung transplant may define patients at high risk of acute lung rejection, and suggest a correlation between acute rejection and effectorMemory T cells in lung transplant recipients.
Unique aspects of rejection and tolerance in liver transplantation.
TLDR
The low incidence of hyperacute or antibody-mediated rejection in liver might be linked to the infrequency of chronic rejection of liver transplants and the availability of better immune monitoring could help develop strategies to recognize tolerance and reduce rejection.
T-cell Exhaustion in Organ Transplantation
TLDR
Harnessing or encouraging the natural processes of exhaustion may provide a novel strategy to promote graft survival and transplantation tolerance.
Deletion of donor-reactive T cell clones following human liver transplantation
TLDR
The results suggest that partial deletion of donor-reactive T cell clones may be a consequence of liver transplantation and does not correlate with success or failure of early immunosuppression withdrawal, demonstrating an impact of the liver allograft after accounting for repertoire turnover.
The Role of Diverse Liver Cells in Liver Transplantation Tolerance
TLDR
The current evidence implicating the tolerogenic properties of diverse liver cells in liver transplantation tolerance is reviewed and proposed liver tolerance mechanisms, such as soluble donor MHC class I molecules, passenger leukocytes theory and a high-load antigen effect are addressed.
Immune Exhaustion and Transplantation
  • A. Sánchez‐Fueyo, J. Markmann
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016
TLDR
Harnessing or encouraging the natural processes of exhaustion may provide a novel means to promote graft survival and transplantation tolerance and the extent of T cell exhaustion occurring with various allografts remains a fertile area for investigation.
Gene Therapy for Tolerance: High-Level Expression of Donor Major Histocompatibility Complex in the Liver Overcomes Naive and Memory Alloresponses to Skin Grafts
TLDR
High-level expression of donor major histocompatibility complex in recipient livers promotes tolerance to skin allografts, even in animals primed to produce a memory response, providing proof of concept for an approach using liver-targeted gene delivery for tolerance induction to donor antigen.
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