Exhaled nitric oxide from lung periphery is increased in COPD.

  title={Exhaled nitric oxide from lung periphery is increased in COPD.},
  author={Caterina Brindicci and Kazuhiro Ito and Onofrio Resta and Neil B. Pride and Peter J Barnes and Sergei A. Kharitonov},
  journal={The European respiratory journal},
  volume={26 1},
Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers and 47 COPD patients of different severity by the classification of the Global Initiative for Chronic… CONTINUE READING


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