Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.

@article{Heinicke2011ExertionalDI,
  title={Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.},
  author={Katja Heinicke and Tanja Taivassalo and Phil Wyrick and Helen Wood and Tony G. Babb and Ronald Gerald Haller},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={301 4},
  pages={R873-84}
}
Exertional dyspnea limits exercise in some mitochondrial myopathy (MM) patients, but the clinical features of this syndrome are poorly defined, and its underlying mechanism is unknown. We evaluated ventilation and arterial blood gases during cycle exercise and recovery in five MM patients with exertional dyspnea and genetically defined mitochondrial defects, and in four control subjects (C). Patient ventilation was normal at rest. During exercise, MM patients had low Vo(2peak) (28 ± 9% of… CONTINUE READING
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