Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice

@article{Pereira2008ExerciseTR,
  title={Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice},
  author={Marcelo Glauber da Silva Pereira and Julio C B Ferreira and Carlos Roberto Emerenciano Bueno and Katt Coelho Mattos and Kaleizu Teodoro Rosa and Maria Claudia Irigoyen and Edilamar Menezes Oliveira and Jos{\'e} Eduardo Krieger and Patr{\'i}cia C Brum},
  journal={European Journal of Applied Physiology},
  year={2008},
  volume={105},
  pages={843-850}
}
The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3–5 month-old mice lacking α2A- and α2C-adrenoceptors (α2A/α2CARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min, 5 days/week. In addition, exercise tolerance, cardiac structural and function analysis were made. At 3 months, fractional shortening and exercise tolerance were similar between groups. At 5 months, α2A/α2CARKO mice… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity - induced heart failure

  • A Medeiros, NP Rolim, +8 authors PC Brum
  • Braz J Med Biol Res
  • 2008
1 Excerpt

Exercise training

  • EM, JE Krieger, CE Negrao, PC Brum
  • 2007

Similar Papers

Loading similar papers…