Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes

@article{OGorman2006ExerciseTI,
  title={Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes},
  author={Donal J. O’Gorman and H{\aa}kan K. R. Karlsson and Stephanie McQuaid and Obada Yousif and Y. M. N. Rahman and Declan Gasparro and Stephan Glund and Alexander V Chibalin and Juleen R Zierath and John J. Nolan},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={2983-2992}
}
Exercise enhances insulin-stimulated glucose transport in skeletal muscle through changes in signal transduction and gene expression. The aim of this study was to assess the impact of acute and short-term exercise training on whole-body insulin-mediated glucose disposal and signal transduction along the canonical insulin signalling cascade. A euglycaemic–hyperinsulinaemic clamp, with vastus lateralis skeletal muscle biopsies, was performed at baseline and 16 h after an acute bout of exercise… CONTINUE READING