Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle.

@article{Ponsot2006ExerciseTI,
  title={Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle.},
  author={Elodie Ponsot and St{\'e}phane P Dufour and Joffrey Zoll and St{\'e}phane Doutrelau and Benoit Banga N'guessan and Bernard G{\'e}ny and Hans H. Hoppeler and Eliane Lampert and Bertrand Mettauer and R Ventura-clapier and Ruddy Richard},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 4},
  pages={
          1249-57
        }
}
This study investigates whether adaptations of mitochondrial function accompany the improvement of endurance performance capacity observed in well-trained athletes after an intermittent hypoxic training program. Fifteen endurance-trained athletes performed two weekly training sessions on treadmill at the velocity associated with the second ventilatory threshold (VT2) with inspired O2 fraction = 14.5% [hypoxic group (Hyp), n = 8] or with inspired O2 fraction = 21% [normoxic group (Nor), n = 7… 
Impairment of maximal aerobic power with moderate hypoxia in endurance athletes: do skeletal muscle mitochondria play a role?
TLDR
A potential role for peripheral factors, including the alteration of cellular homeostasis in active muscles, in determining the tolerance to hypoxia in maximally exercising endurance-trained athletes is suggested.
Hypoxic training: effect on mitochondrial function and aerobic performance in hypoxia.
TLDR
The data suggest that, in moderately trained subjects, 6 wk of hypoxic training possesses no ergogenic effect at sea level and altitude; however, it is not excluded that hypoxia training might facilitate endurance capacity at moderate altitude.
Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans.
  • D. Pesta, F. Hoppel, +7 authors E. Gnaiger
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2011
TLDR
Key mitochondrial adaptations were similar after endurance and strength training, regardless of normoxic or hypoxic exercise, and the limitation of flux by the phosphorylation system was diminished after training.
Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers.
TLDR
It is demonstrated that a 3-wk hypoxic exercise training seems to alter the intrinsic properties of mitochondrial function, i.e., substrate preference, as well as Peak power output (PPO) at sea level without any changes in Vo(2 max) without any significant differences for the Nor group.
Influence of intermittent hypoxic training on muscle energetics and exercise tolerance.
TLDR
IHT does not appreciably alter muscle metabolic responses or incremental exercise performance compared with INT, and changes in muscle metabolite concentrations during exercise were essentially not different between IHT and INT.
The role of haemoglobin mass on VO2max following normobaric ‘live high–train low’ in endurance-trained athletes
TLDR
The present results suggest that LHTL has no positive effect on VO2max in endurance-trained athletes because (i) muscle maximal oxidative capacity is not improved following L HTL and (ii) erythrocyte volume expansion after LHTl, if any, is too small to alter O2 transport.
Intermittent hypoxic training for 6 weeks in 3000 m hypobaric hypoxia conditions enhances exercise economy and aerobic exercise performance in moderately trained swimmers
TLDR
The present findings indicate that the 6 week IHT regime composed of high-intensity aerobic continuous exercise and anaerobic interval exercise can be considered an effective altitude/hypoxic training method for improvement of exercise economy and aerobic exercise performance in moderately trained swimmers.
Training in hypoxia fails to further enhance endurance performance and lactate clearance in well‐trained men and impairs glucose metabolism during prolonged exercise
TLDR
The results show that, compared with training in normoxia, training in hypoxia has no further effect on endurance performance in both normoxic and hypoxic conditions or on lactate metabolic clearance rate, and suggest that training in Hypoxia impairs blood glucose regulation in endurance‐trained subjects during exercise.
Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle.
TLDR
Comparison of ATH vs. SED subjects suggests that regular endurance training at high intensity promotes the enhancement of maximal mitochondrial capacities to oxidize carbohydrate rather than fatty acid and induce specific adaptations of the mitochondrial respiratory chain at the level of complex I.
Effects of Hypoxic Training versus Normoxic Training on Exercise Performance in Competitive Swimmers.
TLDR
The results indicated that the hypoxic training method proposed in this study is effective for improvement of muscular strength and endurance in moderately trained competitive swimmers compared to control group, however, the method resulted in unclear changes in aerobic exercise capacity (VO2max), anaerobic power, and swimming performance of 50 m and 400 m compared to normoxic training.
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