Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.

@article{Kuhl2006ExerciseTD,
  title={Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.},
  author={Jeanette E Kuhl and Neil Bertrand Ruderman and Nicolas Musi and Laurie J Goodyear and Mary Elizabeth Patti and Sarah Crunkhorn and Deepti Dronamraju and Anders Thorell and Jonas O Nygren and Olle Ljungkvist and Marie Degerblad and Agneta St{\aa}hle and Torkel B. Brismar and Kirstine L Andersen and Asish K. Saha and Suad Efend{\'i}c and Peter N B{\aa}venholm},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 6},
  pages={E1296-303}
}
The study was designed to evaluate whether changes in malonyl-CoA and the enzymes that govern its concentration occur in human muscle as a result of physical training. Healthy, middle-aged subjects were studied before and after a 12-wk training program that significantly increased VO2 max by 13% and decreased intra-abdominal fat by 17%. Significant decreases (25-30%) in the concentration of malonyl-CoA were observed after training, 24-36 h after the last bout of exercise. They were accompanied… CONTINUE READING