Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats.

@article{Xu2008ExerciseTC,
  title={Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats.},
  author={Xiaohua Xu and Wenhan Wan and Lisa L. Ji and Shunhua Lao and Anthony S Powers and Weiyan Zhao and John M Erikson and John Q Zhang},
  journal={Cardiovascular research},
  year={2008},
  volume={78 3},
  pages={523-32}
}
AIMS Our aim was to test the hypothesis that angiotensin II receptor blockade combined with exercise training after myocardial infarction (MI) could attenuate post-MI left ventricular remodelling and preserve cardiac function. METHODS AND RESULTS Sprague-Dawley rats underwent ligation of the left descending coronary artery, resulting in MI, or a sham operation. Losartan treatment and exercise training were initiated 1 week after infarction and continued for 8 weeks, either as a single… CONTINUE READING