Exercise training attenuates acute doxorubicin-induced cardiac dysfunction.

  title={Exercise training attenuates acute doxorubicin-induced cardiac dysfunction.},
  author={Adam J. Chicco and Carole M. Schneider and Reid Hayward},
  journal={Journal of cardiovascular pharmacology},
  volume={47 2},
The use of doxorubicin, a highly effective antitumor antibiotic, is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether chronic exercise training (ET) prior to doxorubicin treatment would preserve cardiac function and reduce myocardial oxidative stress following treatment. Rats were exercise trained on a motorized treadmill or confined to sedentary cage activity for 12 weeks, then administered an intraperitoneal injection of doxorubicin (15 mg/kg) or 0… CONTINUE READING


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