Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study.

@article{Gielen2012ExerciseTA,
  title={Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study.},
  author={Stephan Gielen and Marcus Sandri and Irina Kozarez and J{\"u}rgen Kratzsch Kratzsch and Daniel Teupser and Joachim Thiery and Sandra Erbs and Norman Mangner and Karsten Lenk and Rainer Hambrecht and Gerhard A. Schuler and Volker Adams},
  journal={Circulation},
  year={2012},
  volume={125 22},
  pages={
          2716-27
        }
}
BACKGROUND Muscle wasting occurs in both chronic heart failure (CHF) and normal aging and contributes to exercise intolerance and increased morbidity/mortality. However, the molecular mechanisms of muscle atrophy in CHF and their interaction with aging are still largely unknown. We therefore measured the activation of the ubiquitin-proteasome system and the lysosomal pathway of intracellular proteolysis in muscle biopsies of CHF patients and healthy controls in two age strata and assessed the… CONTINUE READING
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