Exercise training and nutritional supplementation for physical frailty in very elderly people.

  title={Exercise training and nutritional supplementation for physical frailty in very elderly people.},
  author={Maria A. Fiatarone and Evelyn F O'Neill and Nancy D Ryan and Karen M. Clements and Gumersindo Solares and Miriam E. Nelson and Susan B. Roberts and Joseph J. Kehayias and Lewis A. Lipsitz and William J Evans},
  journal={The New England journal of medicine},
  volume={330 25},
BACKGROUND Although disuse of skeletal muscle and undernutrition are often cited as potentially reversible causes of frailty in elderly people, the efficacy of interventions targeted specifically at these deficits has not been carefully studied. METHODS We conducted a randomized, placebo-controlled trial comparing progressive resistance exercise training, multinutrient supplementation, both interventions, and neither in 100 frail nursing home residents over a 10-week period. RESULTS The… 

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