Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF‐dependent pathway

@inproceedings{Chrysostomou2016ExerciseRA,
  title={Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF‐dependent pathway},
  author={Vicki Chrysostomou and Sandra Galic and Peter van Wijngaarden and Ian A Trounce and Gregory R Steinberg and Jonathan Guy Crowston},
  booktitle={Aging cell},
  year={2016}
}
Retinal ganglion cells (RGCs) become increasingly vulnerable to injury with advancing age. We recently showed that this vulnerability can be strongly modified in mice by exercise. However, the characteristics and underlying mechanisms of retinal protection with exercise remain unknown. Hence, the aim of this study was to investigate cellular changes associated with exercise-induced protection of aging retinal cells and the role of local and peripheral trophic signalling in mediating these… CONTINUE READING
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