Exercise protects cardiac mitochondria against ischemia-reperfusion injury.

  title={Exercise protects cardiac mitochondria against ischemia-reperfusion injury.},
  author={Youngil Lee and Kisuk Min and Erin E. Talbert and Andreas N. Kavazis and Ashley J. Smuder and Wayne T. Willis and Scott K. Powers},
  journal={Medicine and science in sports and exercise},
  volume={44 3},
PURPOSE Three to five consecutive days of endurance exercise can protect the heart against an ischemia-reperfusion (IR) insult. However, the mechanisms responsible for this exercise-mediated cardioprotection remain unknown. Given the important role that mitochondria play in IR-induced cardiac myocyte injury, we hypothesized that exercise training promotes cardioprotection, at least in part, by increasing mitochondrial antioxidants, preventing mitochondrial release of reactive oxygen species… CONTINUE READING