Exercise prevents diabetes-induced impairment in superficial buffer barrier in porcine coronary smooth muscle.

@article{Witczak2004ExercisePD,
  title={Exercise prevents diabetes-induced impairment in superficial buffer barrier in porcine coronary smooth muscle.},
  author={Carol A Witczak and Michael S Sturek},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 3},
  pages={1069-79}
}
In healthy coronary smooth muscle cells, the superficial sarcoplasmic reticulum (SR) buffers rise in intracellular Ca(2+) levels. In diabetic dyslipidemia, basal Ca(2+) levels are increased, yet Ca(2+) influx is decreased and SR Ca(2+) uptake is increased. Exercise prevents diabetic dyslipidemia-induced increases in basal Ca(2+) levels and decreases in Ca(2+) influx. We tested the hypothesis that diabetic dyslipidemia impairs Ca(2+) extrusion via a decrease in superficial SR and that exercise… CONTINUE READING

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Exercise training reverses the decreased coronary smooth muscle calcium buffering seen in diabetic dyslipidemia (Abstract)

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