Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion

  title={Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion},
  author={Yun-Hong Ding and Chen N. Young and Xiaodong Luan and Jie Li and Jos{\'e} A. Rafols and Justin C. Clark and James Patterson McAllister and Yuchuan Ding},
  journal={Acta Neuropathologica},
There is evidence that physical activity is associated with decreased brain injury resulting from transient middle cerebral artery (MCA) occlusion. We investigated whether exercise could reduce stroke-induced brain inflammatory injury and its associated mediators. Sprague Dawley rats (3 months old) were subjected to 30 min exercise on a treadmill each day for 1–3 weeks. Stroke, in exercised and non-exercised animals, was then induced by a 2-h MCA occlusion followed by 48 h of reperfusion using… CONTINUE READING


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Pre - ischemic motor exercise reduces ischemia / reperfusion injury in rats that correlateds with regional angiogenesis and cellular expression of neurotrophin

  • Y Ding, J Li, JA Rafols, J Clark, JW Phillis, FG Diaz
  • Stroke
  • 2003

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