Exercise plays a preventive role against Alzheimer's disease.

@article{Radk2010ExercisePA,
  title={Exercise plays a preventive role against Alzheimer's disease.},
  author={Zsolt Rad{\'a}k and Nikolett Hart and Linda Sarga and Erika Koltai and Mustafa Atalay and Hideki Ohno and Istvan Boldogh},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={20 3},
  pages={
          777-83
        }
}
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex… 

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References

SHOWING 1-10 OF 94 REFERENCES

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

It is demonstrated that exercise is a simple behavioral intervention sufficient to inhibit the normal progression of AD-like neuropathology in the TgCRND8 mouse model.

Alzheimer’s disease — The ways of prevention

Current epidemiological evidence and new findings from the Finnish population based CAIDE study linking some of these factors to dementia/AD provide an optimistic outlook especially for persons with genetic susceptibility; it may be possible to reduce the risk or postpone the onset of dementia by adopting healthy lifestyle options.

Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model.

Results suggest that exercise training represents a practical therapeutic strategy for human subjects suffering from AD and has the potential for use in new therapeutic strategies for the treatment of other chronic disease including diabetes, cardiovascular and Parkinson's disease.

Physical activity and the maintenance of cognition: Learning from animal models

Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

Several strategies promise amelioration of neurodegenerative developments as judging from in vitro experiments, and especially combinations of drugs that act at different levels might prolong patients' health.

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

  • G. Bu
  • Biology
    Nature Reviews Neuroscience
  • 2009
There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-β peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors.

Exercise and Mental Health: Many Reasons to Move

The overwhelming evidence present in the literature today suggests that exercise ensures successful brain functioning, and during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping delay the onset of neurodegeneration.

Vascular basis of Alzheimer's pathogenesis.

The collective data presented in this review strongly indicate that the present classification of AD is incorrect and should be changed to that of a vascular disorder.

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

It is reported that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults, and provides a promising avenue for therapeutic intervention.

BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study

...