Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.

@article{Kiraly2010ExerciseME,
  title={Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.},
  author={Michael A. Kiraly and Jon Campbell and Edward W Park and Holly E. Bates and Jessica T. Y. Yue and Venketeshwer Rao and Stephen G. Matthews and George J. Bikopoulos and Maria Rozakis-Adcock and Adria Giacca and Mladen Vranic and Michael C Riddell},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 3},
  pages={E671-82}
}
Stress-activated systems and oxidative stress are involved in insulin resistance, which, along with beta-cell failure, contribute to the development of type 2 diabetes mellitus (T2DM). Exercise improves insulin resistance and glucose tolerance, and these adaptations may, in part, be related to reductions in inflammation and oxidative stress. We investigated circulating and tissue-specific markers of inflammation and oxidative stress and insulin-signaling pathways in a rodent model of T2DM, the… CONTINUE READING

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High glucose level and free fatty acid stimulate reactive oxygen species E680 EXERCISE AND HEPATOCYTE PATHOPHYSIOLOGY AJP-Endocrinol Metab

T Inoguchi, P Li, +10 authors H. Nawata
Jne 25, • 2010
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