Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

@article{Maesako2012ExerciseIM,
  title={Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.},
  author={Masato Maesako and Kengo Uemura and Masakazu Kubota and Akira Kuzuya and Kazuki Sasaki and Naoko Hayashida and Megumi Asada-Utsugi and Kiwamu Watanabe and Maiko T Uemura and Takeshi Kihara and Ryosuke Takahashi and Shun Shimohama and Ayae Kinoshita},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 27},
  pages={23024-33}
}
Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD), increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions targeting HFD-induced metabolic dysfunctions may be effective in preventing the development of AD. We previously demonstrated that amyloid precursor protein (APP)-overexpressing transgenic mice fed HFD showed worsening of cognitive function when compared with control APP mice on normal diet. Moreover, we reported that… CONTINUE READING