Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle.

@article{FrydelundLarsen2007ExerciseII,
  title={Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle.},
  author={Lone Frydelund-Larsen and Milena Penkowa and Thorbjorn C A Akerstrom and Alaa Zankari and S. -O. Nielsen and Bente Klarlund Pedersen},
  journal={Experimental physiology},
  year={2007},
  volume={92 1},
  pages={233-40}
}
Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an angiogenic factor in human microvascular endothelial cells by binding to the CXC receptor 2 (CXCR2). In the present study, we examined the expression of the interleukin-8 receptor… CONTINUE READING