Exercise-induced late asthmatic reactions with neutrophil chemotactic activity.

  title={Exercise-induced late asthmatic reactions with neutrophil chemotactic activity.},
  author={Tak Hong Lee and Toshikazu Nagakura and Nikolaos S. Papageorgiou and Yoji Iikura and Antony B. Kay},
  journal={The New England journal of medicine},
  volume={308 25},
Two adults and 13 children with exercise-induced asthma had both immediate and late reductions in forced expiratory volume in one second (FEV1) after treadmill exercise. The late reactions developed 4 to 10 hours after exercise and in each instance were associated with wheezing or chest tightness (or both). Increases in neutrophil chemotactic activity, measured in the 2 adults and in 11 of the children, accompanied the reductions in FEV1 in all these subjects. In contrast, four other adults… CONTINUE READING