Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats.

@article{Xiang2005ExerciseinducedII,
  title={Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats.},
  author={Lusha Xiang and Jay S. Naik and Robert L. Hester},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={288 4},
  pages={
          R987-91
        }
}
  • Lusha Xiang, J. Naik, R. Hester
  • Published 1 April 2005
  • Medicine, Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
The purpose of this study was to test the hypothesis that exercise training improves microvascular function in obese Zucker rats, a model of obesity and type II diabetes. Animals were divided into four age-matched groups: lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE). The exercise groups were treadmill-exercised from 5 to 11 wk of age, including a 2-wk acclimation period. Mean arterial pressure (MAP) was not significantly different between any of the… 
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69 Citations
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Improved functional vasodilation in obese Zucker rats following exercise training.
TLDR
There is a global effect of exercising training to improve insulin resistance and increase functional vasodilation via a decreased TP-mediated vasoconstriction, according to a systemic improved insulin resistance.
Insulin resistance and impaired functional vasodilation in obese Zucker rats.
TLDR
It is suggested that insulin resistance and the resultant increased ROS impair functional dilation in OZRs by increasing TP-mediated vasoconstriction.
Effect of exercise training on calpain systems in lean and obese Zucker rats
TLDR
It is found exercise is useful for BW lossing, especially in the obese rats, and the μ- or m-calpains in skeletal muscle are regulated by exercise in both lean and obese Zucker rats.
Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats
TLDR
Higher exercise intensity induced greater improvements in myocardium antioxidant defenses, while gains in microvascular reactivity appeared to rely more on exercise volume than intensity.
Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats
TLDR
Higher exercise intensity induced greater improvements in myocardium antioxidant defenses, while gains in microvascular reactivity appeared to rely more on exercise volume than intensity.
Voluntary wheel running ameliorates vascular smooth muscle hyper-contractility in type 2 diabetic db/db mice.
  • K. Esser, Wen Su, +6 authors M. Gong
  • Biology, Medicine
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2007
TLDR
The results of this study demonstrated that voluntary wheel running activity was dramatically reduced in db/db mice, but the low levels of running were beneficial, in the absence of effects on obesity or blood glucose, with significant reductions in cardiovascular risk factors and potential delays in beta-cell dysfunction.
Exercise training blunts microvascular rarefaction in the metabolic syndrome.
TLDR
Data suggest that exercise-induced improvements in skeletal muscle MVD in OZR are associated with increased NO bioavailability and may stem from altered inflammatory profiles rather than MMP function.
Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats.
  • J. Frisbee
  • Biology, Medicine
    American journal of physiology. Heart and circulatory physiology
  • 2006
TLDR
Reactive hyperemia following serial arteriolar occlusion was attenuated in OZR versus LZR, treatment with polythethylene glycol-superoxide dismutase was ineffective, and hyperemic responses were improved following inhibition of alpha-adrenoreceptors (alpha1 > alpha2).
Differential vulnerability of skeletal muscle feed arteries to dysfunction in insulin resistance: impact of fiber type and daily activity.
TLDR
It is demonstrated, for the first time, that SFAs from insulin-resistant rats exhibit reduced vulnerability to dysfunction versus GFAs and that physical activity largely prevents GFA dysfunction.
Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats.
TLDR
It is concluded that ExT can alleviate impaired eN OS- and nNOS-dependent responses of pial arterioles during type 1 diabetes and restore impaired ADP- and NMDA-induced vasodilation observed in diabetic rats to that observed in nondiabetics.
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