Exercise-induced activation of the hypothalamic-pituitary-adrenal axis: marked differences in the sensitivity to glucocorticoid suppression.

@article{Petrides1994ExerciseinducedAO,
  title={Exercise-induced activation of the hypothalamic-pituitary-adrenal axis: marked differences in the sensitivity to glucocorticoid suppression.},
  author={J S Petrides and Gregory P Mueller and K T Kalogeras and George P. Chrousos and Philip W. Gold and Patricia Anne Deuster},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 2},
  pages={377-83}
}
Treadmill exercise activates the hypothalamic-pituitary-adrenal axis and evokes metabolic responses proportional to exercise intensity and duration. To determine whether glucocorticoid administration would alter humoral and metabolic regulation during exercise, we administered 4 mg dexamethasone (DEX) or placebo to 11 normal, moderately trained men (19-42 yr old) in a double blinded random fashion 4 h before high intensity intermittent treadmill running. Plasma levels of ACTH, cortisol… CONTINUE READING

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