Exercise-induced activation of NMDA receptor promotes motor unit development and survival in a type 2 spinal muscular atrophy model mouse.

@article{Biondi2008ExerciseinducedAO,
  title={Exercise-induced activation of NMDA receptor promotes motor unit development and survival in a type 2 spinal muscular atrophy model mouse.},
  author={Olivier Biondi and Cl{\'e}ment Grondard and Sylvie L{\'e}colle and S{\'e}verine Deforges and Claude Pariset and Philippe Lopes and Carmen Cifuentes-Diaz and Hung Li and Bruno della Gaspera and Christophe Chanoine and Fr{\'e}d{\'e}ric Charbonnier},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 4},
  pages={
          953-62
        }
}
Spinal muscular atrophy (SMA) is an inborn neuromuscular disorder caused by low levels of survival motor neuron protein, and for which no efficient therapy exists. Here, we show that the slower rate of postnatal motor-unit maturation observed in type 2 SMA-like mice is correlated with the motor neuron death. Physical exercise delays motor neuron death and leads to an increase in the postnatal maturation rate of the motor-units. Furthermore, exercise is capable of specifically enhancing the… CONTINUE READING

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