Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1α Expression*

@article{Wright2007ExerciseinducedMB,
  title={Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1$\alpha$ Expression*},
  author={D. Wright and Dong-Ho Han and P. Garcia-Roves and P. Geiger and T. E. Jones and J. Holloszy},
  journal={Journal of Biological Chemistry},
  year={2007},
  volume={282},
  pages={194 - 199}
}
Exercise results in rapid increases in expression of the transcription coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and in mitochondrial biogenesis in skeletal muscle. PGC-1α regulates and coordinates mitochondrial biogenesis, and overexpression of PGC-1α in muscle cells results in increases in mitochondrial content. In this context, it has been proposed that the increase in PGC-1α protein expression mediates the exercise-induced increase in mitochondrial… Expand
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