Exercise in knee osteoarthritis: do treatment outcomes relate to bone marrow lesions? A randomized trial

@article{Beckwe2017ExerciseIK,
  title={Exercise in knee osteoarthritis: do treatment outcomes relate to bone marrow lesions? A randomized trial},
  author={David Beckw{\'e}e and Peter Vaes and Steven Raeymaeckers and Maryam Shahabpour and Thierry Scheerlinck and Ivan Bautmans},
  journal={Disability and Rehabilitation},
  year={2017},
  volume={39},
  pages={1847 - 1855}
}
Abstract Purpose: Exercise is effective for reducing knee osteoarthritis (OA) pain but effect sizes vary widely. Moreover, not all knee OA patients perceive beneficial effects. Tailoring specific exercises to subgroups of knee OA patients may increase effectivity. Bone marrow lesions (BMLs) have been suggested as a criterion to define such subgroups. This study aimed to investigate whether BMLs’ presence/absence is related to treatment outcomes in a group of knee OA patients who exercised for… 
View on Taylor & Francis
esceo.org
6 Citations
Background Citations
1

6 Citations

Citation Type

Citation Type

Exercise in the management of knee and hip osteoarthritis
TLDR
Osteoarthritis is a complex, multifactorial disease that can be successfully managed and treated through exercise, with minimal risk for negative consequences, but to have greatest impact, appropriate exercise prescription is needed.
Osteoarthritis year in review 2017: rehabilitation and outcomes.
Effectiveness of a Program Combining Strengthening, Stretching, and Aerobic Training Exercises in a Standing versus a Sitting Position in Overweight Subjects with Knee Osteoarthritis: A Randomized Controlled Trial
TLDR
Adding aerobic exercises in an unloaded position to a conventional exercise program produced superior effects over time for self-reported knee pain, knee pain and disability and quality of life compared to loaded aerobic exercises at 24 and 36 sessions in overweight subjects with knee osteoarthritis.
Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis
TLDR
In studies of aerobic exercise in patients with knee OA, very few interventions met guideline-recommended dose; there were small to moderate changes in markers of cardiovascular health and no decrease in marker of systemic inflammation.
Osteoarthritis Progression: Mitigation and Rehabilitation Strategies
TLDR
This review highlights recent therapeutic advancements in osteoarthritis treatment consisting of pharmacologics, nutraceuticals, biologicics, and exercise while emphasizing the current state of post-arthroplasty rehabilitation.
Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials

References

SHOWING 1-10 OF 70 REFERENCES
Knee joint stabilization therapy in patients with osteoarthritis of the knee: a randomized, controlled trial.
Effectiveness of behavioral graded activity in patients with osteoarthritis of the hip and/or knee: A randomized clinical trial.
TLDR
BGA seems to be an acceptable method to treat patients with hip and/or knee OA, with equivalent results compared with UC, and the superiority of BGA over UC has not been demonstrated.
Effectiveness of home exercise on pain and disability from osteoarthritis of the knee: a randomised controlled trial
TLDR
A simple programme of home quadriceps exercises can significantly improve self reported knee pain and function.
Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study.
TLDR
The prevalence and severity of BMLs are associated with less tibial cartilage volume and greater cartilage loss over 2 years and risk of knee joint replacement over 4 years, which provides further support for the importance of B MLs in identifying those with OA most likely to progress.
Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging.
TLDR
Changes in BMLs and synovitis are associated with fluctuations in knee pain in patients with knee OA and similar associations were also observed between these structural lesions and the severity of knee pain.
Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative.
Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker - longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative
TLDR
Large baseline BMLs are associated with greater baseline knee pain, the presence of JSN at baseline, and disease progression, and BML regression is associated with decreased knee pain but not a reduced risk of concurrent JSN progression.
Effectiveness of a home-based exercise therapy and walking program on osteoarthritis of the knee
TLDR
It is concluded that a simple home-based exercise therapy and a regular walking program are effective in treating the symptoms of OA.
The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial
TLDR
Results from this trial will contribute to the evidence regarding the effect of hip strengthening on knee loads and symptoms in people with medial compartment knee OA if shown to reduce the knee adduction moment, hip strengthening has the potential to slow disease progression.
Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review
TLDR
Knee pain in OA is associated with BML and effusion/synovitis suggesting that these features may indicate the origin of pain in knee OA, however, due to the moderate level of evidence these features need to be explored further.
...
1
2
3
4
5
...