Exercise in Myositis

  title={Exercise in Myositis},
  author={Helene Alexanderson},
  journal={Current Treatment Options in Rheumatology},
  pages={289 - 298}
  • H. Alexanderson
  • Published 23 November 2018
  • Medicine
  • Current Treatment Options in Rheumatology
Purpose of the reviewA growing body of evidence supports exercise as a very important part of the treatment for adult patients with idiopathic inflammatory myopathies (IIM). This review mainly focuses on exercise studies published during the last 2 years in adult myositis.Recent findingsDuring the last couple of years, new publications present further evidence for intensive endurance exercise as an anti-inflammatory treatment inducing muscle growth and improving mitochondrial function compared… 
Physical activity in idiopathic inflammatory myopathies: two intervention proposals based on literature review
In IIM patients physical activity improves residual muscle function and prevents muscle atrophy, and the constant practice of physical activity may also lead to cardiopulmonary, endocrine and immunological benefits inIIM patients.
Physical exercise for the management of systemic autoimmune myopathies: recent findings, and future perspectives
Physical exercise, as already consolidated in the literature, is an effective, well tolerated, and low-cost strategy for patients with myopathies.
The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training
Low-load blood flow restriction exercise elicited an upregulation in CD3−/CD8+ expressing natural killer cell content, which suggests that 12 weeks of BFRE training evokes an amplified immune response in sIBM muscle.
Feasibility of a blended therapy approach in the treatment of patients with inflammatory myopathies
Blended therapy combining the use of an interactive tablet-based resistance training program with face-to-face therapy sessions is feasible and safe and participants` acceptance with this approach was high.
Impact and Management of Dysphagia in Inflammatory Myopathies
Evaluation of dysphagia in myositis requires thorough clinical workup and appropriate instrumental procedures, and controlled trials and consensus on best patient care are required for this important symptom.
Dysphagia in Patients with Sporadic Inclusion Body Myositis: Management Challenges
Dysphagia in inclusion body myositis is common and associated with increased mortality and morbidity due to aspiration pneumonia, malnutrition and dehydration and increased knowledge of the aetiopathogenesis is likely to change the approach to treatment and improve the quality of life for patients.
Inflammatory Myopathies: Utility of Antibody Testing.
The effect of a 24-week training focused on activities of daily living, muscle strengthening, and stability in idiopathic inflammatory myopathies: a monocentric controlled study with follow-up
This 24-week supervised intervention focused on ADL training proved to be safe and effective and prevented the progressive deterioration, but also resulted in a significant improvement in muscle strength, endurance, stability, and disability, which was clinically meaningful in a substantial proportion of patients.
Učinkovitost i sigurnost tjelovježbe u idiopatskim upalnim miopatijama– prikaz bolesnika i pregled literature
A 3-year clinical course of a patient diagnozed with an anti-SRP positive myositis with a special review of stationary rehabilitation in the acute stage of the disease is presented and review of the literature is presented.


Physical exercise as a treatment for adult and juvenile myositis
Data suggest that intensive aerobic exercise and resistance training could reduce disease activity and inflammation and improve muscle metabolism.
Exercise as an Adjuvant Treatment in Persistent Active Polymyositis
The findings herein suggest that a combined aerobic and strength training program may be tolerable and potentially effective in improving muscle function, aerobic conditioning, and quality of life in patients with persistent active polymyositis.
New Insights into the Benefits of Exercise for Muscle Health in Patients with Idiopathic Inflammatory Myositis
Reports seeking mechanisms underlying effects of exercise in skeletal muscle indicate increased aerobic capacity, activation of genes in aerobic phenotype and muscle growth programs, and down regulation in genes related to inflammation demonstrating that exercise is fundamental to improve muscle performance and health in IIM.
Intensive exercise and a patient in acute phase of polymyositis.
It is concluded that short-term intensive training and exercise may lead to improvements in patients with polymyositis, without causing a progress in the disease.
Resistance training with vascular occlusion in inclusion body myositis: a case study.
A novel, and likely the first, nonpharmacological therapeutic tool that might be able to counteract the muscle atrophy and the declining strength that usually occur in IBM is described.
Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction.
The home exercise program was considered as not harmful to the muscles regarding muscle inflammation and function and may prevent loss of muscle strength due to disease and/or inactivity.
Abnormal lactate levels in patients with polymyositis and dermatomyositis: the benefits of a specific rehabilitative program.
A specific aerobic training program reduced lactate levels and relieved fatigue symptoms in a within-group of four of the PM patients, suggesting an impaired muscle oxidative efficiency in PM/DM patients.
Safety of a home exercise programme in patients with polymyositis and dermatomyositis: a pilot study.
The results indicate that this home exercise programme can be safely employed in patients with stable, inactive polymyositis and dermatomyositis, with beneficial effects on muscle function.
Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes.
Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis.
Patients with chronic, stable PM and DM can perform this intensive resistive exercise program with beneficial effects on impairment and activity limitation without increased muscle inflammation.