Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation.

@article{Odonnell2002ExerciseHI,
  title={Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation.},
  author={Denis O'donnell and Christine Linda D'Arsigny and Michael Fitzpatrick and Katherine Alexandra Webb},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={166 5},
  pages={663-8}
}
In severe chronic obstructive pulmonary disease (COPD), carbon dioxide retention during exercise is highly variable and is poorly predicted by resting pulmonary function and arterial blood gases or by tests of ventilatory control. We reasoned that in patients with compromised gas exchange capabilities, exercise hypercapnia could be explained, in part, by the restrictive consequences of dynamic lung hyperinflation. We studied 20 stable patients with COPD (FEV(1) = 34 +/- 3 percent predicted… CONTINUE READING

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