Exercise hormone irisin is a critical regulator of cognitive function.

@article{Islam2021ExerciseHI,
  title={Exercise hormone irisin is a critical regulator of cognitive function.},
  author={Mohammad Rashedul Islam and Sophia Valaris and Michael F Young and Erin B Haley and Renhao Luo and Sabrina F Bond and Sofia Mazuera and Robert R. Kitchen and Barbara J. Caldarone and Luis E. B. Bettio and Brian R. Christie and Angela B. Schmider and Roy J. Soberman and Antoine Besnard and Mark P. Jedrychowski and Hyeonwoo Kim and Hua Tu and Eunhee Kim and Se Hoon Choi and Rudolph E. Tanzi and Bruce M Spiegelman and Christiane D Wrann},
  journal={Nature metabolism},
  year={2021},
  volume={3 8},
  pages={
          1058-1070
        }
}
Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here, we show that irisin, the cleaved and circulating form of the exercise-induced membrane protein FNDC5, is sufficient to confer the benefits of exercise on cognitive function. Genetic deletion of Fndc5/irisin (global Fndc5 knock-out (KO) mice; F5KO) impairs cognitive function in exercise, ageing and AD. Diminished… 
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Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer’s disease
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