Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring.

  title={Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring.},
  author={Arne Herring and Anja Donath and Maksym Yarmolenko and Ellen Uslar and Catharina Conzen and Dimitrios Kanakis and Claudius Bosma and Karl Worm and W. Paulus and Kathy Keyvani},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={26 1},
Physical activity protects brain function in healthy individuals and those with Alzheimer's disease (AD). Evidence for beneficial effects of parental exercise on the health status of their progeny is sparse and limited to nondiseased individuals. Here, we questioned whether maternal running interferes with offspring's AD-like pathology and sought to decipher the underlying mechanisms in TgCRND8 mice. Maternal stimulation was provided by voluntary wheel running vs. standard housing during… CONTINUE READING