Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats.

@article{Asghar2007ExerciseDO,
  title={Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats.},
  author={Mohammad Asghar and Liza George and Mustafa F. Lokhandwala},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 3},
  pages={
          F914-9
        }
}
Recently, we reported that oxidative stress decreases D1 receptor numbers and G protein activation in renal proximal tubules (RPT), resulting in diminished natriuretic response to dopamine in old rats. We tested the hypothesis that exercise in old rats will decrease oxidative stress and restore natriuretic response to D1 receptor agonist, SKF 38393. Old (23 mo) rats were subjected to rest (sedentary) or to treadmill exercise followed by measurement of oxidative stress [malondialdehyde (MDA… 
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TLDR
Impaired redox homeostasis is substantially more prominent in males than females, and the renal tissue proteins and lipids in different genders may have different susceptibilities to oxidative damage.
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