Exercise as an add-on strategy for the treatment of major depressive disorder: a systematic review

@article{Mura2014ExerciseAA,
  title={Exercise as an add-on strategy for the treatment of major depressive disorder: a systematic review},
  author={Gioia Mura and Maria Francesca Moro and Scott B. Patten and Mauro Giovanni Carta},
  journal={CNS Spectrums},
  year={2014},
  volume={19},
  pages={496 - 508}
}
Antidepressants are currently the treatment of choice for major depressive disorder (MDD). Nevertheless, a high percentage of patients do not respond to a first-line antidepressant drug, and combination treatments and augmentation strategies increase the risk of side effects. Moreover, a significant proportion of patients are treatment-resistant. In the last 30 years, a number of studies have sought to establish whether exercise could be regarded as an alternative to antidepressants, but so far… 
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References

SHOWING 1-10 OF 100 REFERENCES
Physical Activity in Depressed Elderly. A Systematic Review
  • G. Mura, M. Carta
  • Psychology, Medicine
    Clinical practice and epidemiology in mental health : CP & EMH
  • 2013
TLDR
To establish the new findings on the effectiveness of exercise on depression in elderlies, a search of significant articles in PubMed/Medline found some promising findings on physical activity combined with antidepressants in treatment resistant late life depression.
Treatment-resistant depression: therapeutic trends, challenges, and future directions
  • K. S. Al-Harbi
  • Psychology, Medicine
    Patient preference and adherence
  • 2012
TLDR
Treatment-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients with the disorder.
Moderate exercise improves depression parameters in treatment-resistant patients with major depressive disorder.
Treatment-resistant depression: no panacea, many uncertainties. Adverse effects are a major factor in treatment choice.
  • Medicine, Psychology
    Prescrire international
  • 2011
TLDR
Maintaining a good quality relationship between patient and doctor may be more important than attempting to obtain remission "at any cost", and adverse effects must be taken into account in the choice of drug(s).
Effects of exercise training on older patients with major depression.
TLDR
After 16 weeks of treatment exercise was equally effective in reducing depression among patients with MDD, and an exercise training program may be considered an alternative to antidepressants for treatment of depression in older persons.
Exercise for depression.
TLDR
The effectiveness of exercise in the treatment of depression in adults compared with no treatment or a comparator intervention was determined and there were multiple sources of bias in many of the trials.
Efficacy of physical activity in the adjunctive treatment of major depressive disorders: preliminary results
TLDR
Physical activity seems a good adjunctive treatment in the long term management of patients with MDD.
Exercise and severe depression: preliminary results of an add-on study.
Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis
TLDR
It is concluded that physical exercise improves the response to treatment, especially aerobic training, however, the efficacy of exercise in the treatment of depression was influenced by age and severity of symptoms.
Exercise and the Treatment of Clinical Depression in Adults
TLDR
More data from carefully conducted clinical trials are needed before exercise can be recommended as an alternative to more traditional, empirically validated pharmacological and behavioural therapies, however, many studies have significant methodological limitations.
...
1
2
3
4
5
...