Exercise as a therapeutic modality in patients with idiopathic inflammatory myopathies

@article{Alexanderson2012ExerciseAA,
  title={Exercise as a therapeutic modality in patients with idiopathic inflammatory myopathies},
  author={Helene Alexanderson and Ingrid E. Lundberg},
  journal={Current Opinion in Rheumatology},
  year={2012},
  volume={24},
  pages={201–207}
}
Purpose of reviewTo present scientific evidence on clinical and molecular effects of exercise in adult and juvenile idiopathic inflammatory myopathies focusing on recent studies. Recent findingsIn patients with inclusion body myositis (IBM), one small, open study recently for the first time reported on improved muscle strength and functional capacity after a twice-a-day home exercise programme, whereas earlier studies have not been able to show any or only small improvements, mainly in less… 
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TLDR
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References

SHOWING 1-10 OF 49 REFERENCES
A Longitudinal, Integrated, Clinical, Histological and mRNA Profiling Study of Resistance Exercise in Myositis
TLDR
The changes in gene expression reported in the present study are in agreement with the performance improvements induced by exercise and suggest that resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle.
Anaerobic exercise capacity in patients with juvenile-onset idiopathic inflammatory myopathies.
TLDR
The WAnT might be a valuable adjunct next to other assessment tools in the followup of JIIM patients and correlated with disease phase and with knee extensor muscle strength.
Responsiveness to exercise training in juvenile dermatomyositis: a twin case study
TLDR
This was the first report to describe the training response of a patient with non-active JDM following an exercise training regimen and exhibited improved strength, muscle function and aerobic conditioning without presenting an exacerbation of the disease.
Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction.
TLDR
The home exercise program was considered as not harmful to the muscles regarding muscle inflammation and function and may prevent loss of muscle strength due to disease and/or inactivity.
Responsiveness of exercise parameters in children with inflammatory myositis.
TLDR
It is found that children with active juvenile DM had significantly reduced exercise parameters compared with a remission period and several parameters had very good responsiveness, with previously established validity and reliability.
Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial.
TLDR
Oral creatine supplements combined with home exercises improve functional performance without significant adverse effects in patients with polymyositis or dermatomyositis and appear safe, effective, and inexpensive.
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls.
The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis.
TLDR
It seems that this exercise program safely can be employed in patients with active PM or DM, and it is suggested that physical exercise should be included in the rehabilitation of these patients.
Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis.
TLDR
Patients with chronic, stable PM and DM can perform this intensive resistive exercise program with beneficial effects on impairment and activity limitation without increased muscle inflammation.
Safety of a home exercise programme in patients with polymyositis and dermatomyositis: a pilot study.
TLDR
The results indicate that this home exercise programme can be safely employed in patients with stable, inactive polymyositis and dermatomyositis, with beneficial effects on muscle function.
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