Exercise and the Regulation of Adipose Tissue Metabolism.

@article{Tsiloulis2015ExerciseAT,
  title={Exercise and the Regulation of Adipose Tissue Metabolism.},
  author={Thomas Tsiloulis and Matthew J. Watt},
  journal={Progress in molecular biology and translational science},
  year={2015},
  volume={135},
  pages={
          175-201
        }
}
  • T. TsiloulisM. Watt
  • Published 2015
  • Biology
  • Progress in molecular biology and translational science
View on PubMed
doi.org
56 Citations
Highly Influential Citations
2
Background Citations
28
Results Citations
1

Figures and Tables from this paper

56 Citations

The Regulation of Fat Metabolism during Aerobic Exercise

Some studies concerning the relationship between exercise and the aforementioned processes also in light of hormonal controls and molecular regulations within fat and skeletal muscle cells are reported.

Exercise-induced ‘browning’ of adipose tissues

The Effect of Exercise on Beige Adipose Tissue

An increase in various cytokines and important genes involved in this process, occurring with different types of exercises at various levels, revealed that exercises could be considered as one of the possible treatments for obesity and metabolic syndrome.

The Importance of Fatty Acids as Nutrients during Post-Exercise Recovery

A high FA turnover in recovery seems essential to regain whole-body substrate homeostasis after aerobic endurance exercise.

Exercise Improves Redox Homeostasis and Mitochondrial Function in White Adipose Tissue

Results show that chronic exercise modulates redox homeostasis in WAT, improving antioxidant capacity, and mitochondrial function, and reduced the phosphorylation levels of H2AX histone, a central protein that contributes to genome stability through the signaling of DNA damage.

Exercise and Activation of Brown Adipose Tissue

The origin of brown adipose tissue and biological mechanism of BAT activation will be reviewed, previous results on BAT activation after exercise training will be discussed and the effect of exercise in BAT activation has been controversial.

The Effect of Acute Aerobic Exercise on Redox Homeostasis and Mitochondrial Function of Rat White Adipose Tissue

The results suggest that one session of aerobic exercise can induce a transient prooxidative state in WAT, followed by an increase in antioxidant and cytoprotective gene expression.

Adipose tissue development and the molecular regulation of lipid metabolism.

New developments in understanding the phenotype of APCs are outlined and evidence suggesting that APCs differ between distinct adipose tissue depots and are affected by obesity is provided.

Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity

The similarities and differences of cold exposure and exercise in relation to their effects on BAT activity and metabolism and its relevance for the prevention of obesity and the development of type 2 diabetes are discussed.

Adipocyte Specific Signaling

Emerging insights of these processes, particularly adipogenesis and adipocyte browning, are discussed, as promising therapeutic targets for obesity and other common metabolic disorders.
...

120 References

Exercise Training Induces Mitochondrial Biogenesis and Glucose Uptake in Subcutaneous Adipose Tissue Through eNOS-Dependent Mechanisms

It is observed that swim training increases mitochondrial biogenesis, mitochondrial DNA content, and glucose uptake in subcutaneous adipose tissue of WT but not eNOS−/− mice after a swim training period, and in vitro effects of NO on mouse 3T3-L1 and human sub cutaneous adiposity–derived adipocytes after a chronic treatment with an NO donor: diethylenetriamine-NO (DETA-NO).

Lipolysis and lipid mobilization in human adipose tissue.

Adenosine, Adenosine Receptors and Their Role in Glucose Homeostasis and Lipid Metabolism

This review focuses on the role and significance of different adenosine receptors in mediating the effect ofadenosine on glucose and lipid homeostasis.

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.

HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle, and studies in 3T3-L1 adipocytes revealed important tissue differences in the regulation of HSL.

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration.

It is concluded that, whereas carbohydrate availability is regulated directly in relation to exercise intensity, the regulation of lipid metabolism seems to be more complex.

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.

Post‐exercise adipose tissue and skeletal muscle lipid metabolism in humans: the effects of exercise intensity

It is concluded that the lipolytic rate in abdominal subcutaneous adipose tissue during exercise is the same whether the relative workload is 40 % or 60 % of maximum, and there is a substantial lipid mobilization from adiposes tissue and only a small fraction of this is taken up in the lower extremities.

A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

It is shown in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin, which results in improvements in obesity and glucose homeostasis.

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice.

An essential role is demonstrated for both ATGL and HSL in maintaining adequate FFA supply to sustain normal substrate metabolism at rest and during exercise.

Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase

The results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
...