Exercise- and hypertension-induced collagen changes are related to left ventricular function in rat hearts.

@article{Burgess1996ExerciseAH,
  title={Exercise- and hypertension-induced collagen changes are related to left ventricular function in rat hearts.},
  author={M. Loring Burgess and James Buggy and Robert L. Price and Francis L. Abel and Louis Terracio and Allen M. Samarel and Thomas Keith Borg},
  journal={The American journal of physiology},
  year={1996},
  volume={270 1 Pt 2},
  pages={H151-9}
}
Chronic hypertension, known to affect the collagen profile of the heart, and exercise result in impaired or improved heart function, respectively. Collagen types I [alpha 1(I)2 and alpha 2(I)] and III [alpha 1(III)3] are the predominant interstitial collagens thought to influence cardiac function, and the ratio of type III to I (collagen III/I) is thought to be a significant factor in the altered relaxation observed in hypertrophy. The present study tested the hypothesis that the myocardial… CONTINUE READING

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