Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.

@article{Choi2006ExerciseAD,
  title={Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.},
  author={Soo Bong Choi and Jin Sun Jang and Sang Mee Hong and Dong Wha Jun and Sunmin Park},
  journal={The Journal of endocrinology},
  year={2006},
  volume={190 2},
  pages={471-82}
}
Long-term dexamethasone (DEX) treatment is well known for its ability to increase insulin resistance in liver and adipose tissues leading to hyperinsulinemia. On the other hand, exercise enhances peripheral insulin sensitivity. However, it is not clear whether DEX and/or exercise affect beta-cell mass and function in diabetic rats, and whether their effects can be associated with the modulation of the insulin/IGF-I signaling cascade in pancreatic beta-cells. After an 8-week study, whole body… CONTINUE READING
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