Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.

@article{Starkie2003ExerciseAI,
  title={Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.},
  author={Rebecca L Starkie and Sisse Rye Ostrowski and Sune Jauffred and Mark Anthony Febbraio and Bente Klarlund Pedersen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 8},
  pages={884-6}
}
During "nondamaging" exercise, skeletal muscle markedly releases interleukin (IL)-6, and it has been suggested that one biological role of this phenomenon is to inhibit the production of tumor necrosis factor (TNF)- alpha, which is known to cause pathogenesis such as insulin resistance and atherosclerosis. To test this hypothesis, we performed three experiments in which eight healthy males either rested (CON), rode a bicycle for 3 h (EX), or were infused with recombinant human IL-6 (rhIL-6) for… CONTINUE READING
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