Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive.

@article{Kang2009ExerciseAO,
  title={Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive.},
  author={Chounghun Kang and Kathleen M O'Moore and Jonathan R. Dickman and Li Li Ji},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 10},
  pages={1394-400}
}
The peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha)-activated signal transduction pathway has previously been shown to stimulate mitochondrial biogenesis in skeletal muscle in response to endurance exercise. In vitro data indicate that PGC-1alpha signaling may be sensitive to reactive oxygen species (ROS) but its role in vivo is not clear. The objectives of this study were (1) to investigate whether the PGC-1alpha pathway could be activated by a single bout of… CONTINUE READING
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