Exercise activates the endocannabinoid system

  title={Exercise activates the endocannabinoid system},
  author={Phillip B. Sparling and Andrea Giuffrida and Daniele Piomelli and Linda B. Rosskopf and A Dietrich},
Extensive documentation exists showing that exercise induces analgesia and sedation. Despite decades of research attempting to explicate a neurochemical basis for these phenomena, the mechanism underlying these changes is unknown. Using trained male college students running on a treadmill or cycling on a stationary bike for 50 min at 70–80% of maximum heart rate, we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new… 

Endocannabinoids and exercise

An overview of this emerging field of exercise-induced analgesia, sedation, anxiolysis, and a sense of wellbeing is provided.

The endocannabinoid system mediates aerobic exercise-induced antinociception in rats

Endogenous systems involved in exercise-induced analgesia.

This review aims to provide the reader with an in-depth description of the main endogenous systems, substances, neurotransmitters, receptors and enzymes that are thought to be involved in the analgesic effect induced by exercise.

Exercise-induced endocannabinoid signaling is modulated by intensity

The results are consistent with intensity-dependent psychological state changes with exercise and support the hypothesis that eCB activity is related to neurobiological effects of exercise, and future studies examining the role of exercise-induced eCB signaling on neurobiology or physiology must take exercise intensity into account.

The Endocannabinoid System as a Potential Mechanism through which Exercise Influences Episodic Memory Function

A complementary mechanistic model is discussed, suggesting that the endocannabinoid system may, in part, influence the effects of exercise on memory function.

Mechanisms of exercise-induced hypoalgesia.

Effects of Aerobic Exercise on Mood and Human Opioidergic Activation Measured by Positron Emission Tomography

This chapter provides an overview on the applicability of positron emission tomography ligand activation studies with opioidergic tracers for imaging endogenous opioids transmission associated with exercise.



A second endogenous cannabinoid that modulates long-term potentiation

2-AG activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses, indicating that 2-AG is a second endogenous cannabinoid ligand in the central nervous system.

Cannabinoids modulate pain by multiple mechanisms of action

β-endorphin (1-31) in the plasma of male volunteers undergoing physical exercise

Control of pain initiation by endogenous cannabinoids

It is shown that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS, and that locally generated an andamide and PEA may mediate this effect.

Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.

The findings suggest that cannabinoids selectively modulate the activity of nociceptive neurons in the spinal dorsal horn by actions at CB1 receptors, which represents a suppression of pain neurotransmission.

THIS ARTICLE HAS BEEN RETRACTED Activation of capsaicin‐sensitive primary sensory neurones induces anandamide production and release

Findings indicate that activation of capsaicin‐sensitive primary sensory neurones evokes anandamide production and release, and that an andamide might be a key endogenous regulator of the excitability of these neurones.

Behavioral effects of cannabinoid agents in animals.

In animals, cannabinoid agonists such as delta9-THC, WIN 55,212-2, and CP 55,940 produce a characteristic combination of four symptoms, hypothermia, analgesia, hypoactivity, and catalepsy, providing good evidence for the involvement of CB1-related mechanisms.

Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry.

The method was applied to the quantification of anandamide, PEA, and OEA in plasma prepared from rat blood collected either by cardiac puncture or by decapitation, and found that disruptive procedures of blood collection may result in gross overestimates in the concentrations of circulating AEs.

Pain and exercise.

  • H. Hislop
  • Education
    The Physical therapy review
  • 1960