Exercise activates the endocannabinoid system

@article{Sparling2003ExerciseAT,
  title={Exercise activates the endocannabinoid system},
  author={Phillip B. Sparling and Andrea Giuffrida and Daniele Piomelli and Linda B. Rosskopf and A Dietrich},
  journal={NeuroReport},
  year={2003},
  volume={14},
  pages={2209-2211}
}
Extensive documentation exists showing that exercise induces analgesia and sedation. Despite decades of research attempting to explicate a neurochemical basis for these phenomena, the mechanism underlying these changes is unknown. Using trained male college students running on a treadmill or cycling on a stationary bike for 50 min at 70–80% of maximum heart rate, we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new… 

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References

SHOWING 1-10 OF 11 REFERENCES

A second endogenous cannabinoid that modulates long-term potentiation

TLDR
2-AG activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses, indicating that 2-AG is a second endogenous cannabinoid ligand in the central nervous system.

Cannabinoids modulate pain by multiple mechanisms of action

β-endorphin (1-31) in the plasma of male volunteers undergoing physical exercise

Control of pain initiation by endogenous cannabinoids

TLDR
It is shown that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS, and that locally generated an andamide and PEA may mediate this effect.

Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.

TLDR
The findings suggest that cannabinoids selectively modulate the activity of nociceptive neurons in the spinal dorsal horn by actions at CB1 receptors, which represents a suppression of pain neurotransmission.

THIS ARTICLE HAS BEEN RETRACTED Activation of capsaicin‐sensitive primary sensory neurones induces anandamide production and release

TLDR
Findings indicate that activation of capsaicin‐sensitive primary sensory neurones evokes anandamide production and release, and that an andamide might be a key endogenous regulator of the excitability of these neurones.

Behavioral effects of cannabinoid agents in animals.

TLDR
In animals, cannabinoid agonists such as delta9-THC, WIN 55,212-2, and CP 55,940 produce a characteristic combination of four symptoms, hypothermia, analgesia, hypoactivity, and catalepsy, providing good evidence for the involvement of CB1-related mechanisms.

Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry.

TLDR
The method was applied to the quantification of anandamide, PEA, and OEA in plasma prepared from rat blood collected either by cardiac puncture or by decapitation, and found that disruptive procedures of blood collection may result in gross overestimates in the concentrations of circulating AEs.

Pain and exercise.

  • H. Hislop
  • Education
    The Physical therapy review
  • 1960